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There are 16 matchups on the NFL’s Week 13 card, with the Chargers (-1.5) among the best bets versus the spread, according to our projections. For more suggestions, including parlay opportunities, scroll down.

NFL Picks Against the Spread – Week 13

Jump to Matchup:

Pick: Chargers -1.5 vs. Falcons

• Matchup: Los Angeles Chargers at Atlanta Falcons
• Projected Winner & Margin: Chargers by 3.1 points ()
• Spread: Chargers -1.5
• Time: 1 p.m. ET
• Date: Dec. 1
• TV Channel: CBS
• Live Stream: | (Regional restrictions may apply)

Pick: Seahawks -2 vs. Jets

• Matchup: Seattle Seahawks at New York Jets
• Projected Winner & Margin: Seahawks by 4.0 points ()
• Spread: Seahawks -2
• Time: 1 p.m. ET
• Date: Dec. 1
• TV Channel: FOX
• Live Stream: (Regional restrictions may apply)

Pick: Colts -2.5 vs. Patriots

• Matchup: Indianapolis Colts at New England Patriots
• Projected Winner & Margin: Colts by 5.4 points ()
• Spread: Colts -2.5
• Time: 1 p.m. ET
• Date: Dec. 1
• TV Channel: CBS
• Live Stream: | (Regional restrictions may apply)

Pick: Packers -3 vs. Dolphins

• Matchup: Miami Dolphins at Green Bay Packers
• Projected Winner & Margin: Packers by 16.6 points ()
• Spread: Packers -3
• Time: 8:20 p.m. ET
• Date: Nov. 28
• TV Channel: NBC
• Live Stream: (Regional restrictions may apply)

Pick: Steelers +3 vs. Bengals

• Matchup: Pittsburgh Steelers at Cincinnati Bengals
• Projected Winner & Margin: Steelers by 5.0 points ()
• Spread: Bengals -3
• Time: 1 p.m. ET
• Date: Dec. 1
• TV Channel: CBS
• Live Stream: | (Regional restrictions may apply)

Pick: Saints +3 vs. Rams

• Matchup: Los Angeles Rams at New Orleans Saints
• Projected Winner & Margin: Rams by 0.6 points ()
• Spread: Rams -3
• Time: 4:05 p.m. ET
• Date: Dec. 1
• TV Channel: FOX
• Live Stream: (Regional restrictions may apply)

Pick: Eagles +3 vs. Ravens

• Matchup: Philadelphia Eagles at Baltimore Ravens
• Projected Winner & Margin: Eagles by 0.3 points ()
• Spread: Ravens -3
• Time: 4:25 p.m. ET
• Date: Dec. 1
• TV Channel: CBS
• Live Stream: | (Regional restrictions may apply)

Pick: Cowboys -3.5 vs. Giants

• Matchup: New York Giants at Dallas Cowboys
• Projected Winner & Margin: Cowboys by 5.2 points ()
• Spread: Cowboys -3.5
• Time: 4:30 p.m. ET
• Date: Nov. 28
• TV Channel: FOX
• Live Stream: (Regional restrictions may apply)

Pick: Vikings -3.5 vs. Cardinals

• Matchup: Arizona Cardinals at Minnesota Vikings
• Projected Winner & Margin: Vikings by 6.1 points ()
• Spread: Vikings -3.5
• Time: 1 p.m. ET
• Date: Dec. 1
• TV Channel: FOX
• Live Stream: (Regional restrictions may apply)

Pick: Texans -5 vs. Jaguars

• Matchup: Houston Texans at Jacksonville Jaguars
• Projected Winner & Margin: Texans by 7.9 points ()
• Spread: Texans -5
• Time: 1 p.m. ET
• Date: Dec. 1
• TV Channel: FOX
• Live Stream: (Regional restrictions may apply)

Pick: Commanders -5.5 vs. Titans

• Matchup: Tennessee Titans at Washington Commanders
• Projected Winner & Margin: Commanders by 11.3 points ()
• Spread: Commanders -5.5
• Time: 1 p.m. ET
• Date: Dec. 1
• TV Channel: CBS
• Live Stream: | (Regional restrictions may apply)

Pick: Broncos -5.5 vs. Browns

• Matchup: Cleveland Browns at Denver Broncos
• Projected Winner & Margin: Broncos by 17.5 points ()
• Spread: Broncos -5.5
• Time: 8:15 p.m. ET
• Date: Dec. 2
• TV Channel: ESPN
• Live Stream: (Regional restrictions may apply)

Pick: Buccaneers -6 vs. Panthers

• Matchup: Tampa Bay Buccaneers at Carolina Panthers
• Projected Winner & Margin: Buccaneers by 19.8 points ()
• Spread: Buccaneers -6
• Time: 4:05 p.m. ET
• Date: Dec. 1
• TV Channel: FOX
• Live Stream: (Regional restrictions may apply)

Pick: Bills -7 vs. 49ers

• Matchup: San Francisco 49ers at Buffalo Bills
• Projected Winner & Margin: Bills by 14.2 points ()
• Spread: Bills -7
• Time: 8:20 p.m. ET
• Date: Dec. 1
• TV Channel: NBC
• Live Stream: (Regional restrictions may apply)

Pick: Lions -10 vs. Bears

• Matchup: Chicago Bears at Detroit Lions
• Projected Winner & Margin: Lions by 23.8 points ()
• Spread: Lions -10
• Time: 12:30 p.m. ET
• Date: Nov. 28
• TV Channel: CBS
• Live Stream: | (Regional restrictions may apply)

Pick: Chiefs -12.5 vs. Raiders

• Matchup: Las Vegas Raiders at Kansas City Chiefs
• Projected Winner & Margin: Chiefs by 20.4 points ()
• Spread: Chiefs -12.5
• Time: 3 p.m. ET
• Date: Nov. 29
• TV Channel: Amazon Prime Video
• Live Stream: (Regional restrictions may apply)

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